Localization Versus Function of Rab3 Proteins
نویسندگان
چکیده
منابع مشابه
Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion.
Rab3A, Rab3B, Rab3C, and Rab3D constitute a family of GTP-binding proteins that are implicated in regulated exocytosis. Various localizations and distinct functions have been proposed for different and occasionally even for the same Rab3 protein. This is exemplified by studies demonstrating that deletion of Rab3A in knock-out mice results in dysregulation of the final stages of exocytosis, wher...
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Three lines of evidence suggest that rabphilin and rab3 dissociation occur in conjunction with Ca-triggered A felicitous convergence of independent lines of resynaptic vesicle fusion, and that they occur after docksearch, biochemistry in mammals and genetics in C. ing but before endocytosis of vesicles: 1. Tetanus and elegans, has given us unexpected insight into the biolbotulinum toxins inhibi...
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Rab3A, Rab3B, Rab3C, and Rab3D are closely related GTP-binding proteins of synaptic vesicles that may function in neurotransmitter release. We have produced knock-out (KO) mice for Rab3B and Rab3C and crossed them with previously generated Rab3A and 3D knock-out mice to generate double, triple, and quadruple Rab3 knock-out mice. We have found that all single and double Rab3 knock-out mice are v...
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15 صفحه اولRab3 GTPase Lands Bruchpilot
Active zones are the sites of neurotransmitter release, but their assembly mechanisms are poorly understood. In this issue of Neuron, Graf et al. perform a genetic screen in Drosophila and uncover a novel role for the Rab3 GTPase in organizing the active zone at the neuromuscular junction.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m203704200